Velocity control of nanoliter droplets using a pneumatic dispensing system
© Lee et al.; licensee Springer 2014
Received: 19 March 2014
Accepted: 19 May 2014
Published: 12 July 2014
This paper introduces a pneumatic dispensing system to control the velocity of nanoliter droplets with small variation of volume. The system consists of a flexible membrane integrated with a backflow stopper. This unique dispensing mechanism can control the velocity of droplets according to applied positive pressures regardless of other operating conditions and design parameters. The range of droplet velocities is shifted by the flow resistance at the outlet under the same cross-section area. Our dispensing system can eject droplets of desired volume at a velocity that can be easily controlled by selecting design parameters and operating conditions. This dispensing system will provide a reliable performance within an optimized condition stably to deposit droplets onto accurate locations.
Microdispensing systems (e.g., inkjet printing system), which can precisely deposit small volumes of functional materials, provide a low cost process in aspect of saving materials and a flexible method because of forming micropatterns directly without masks for patterning [–]. The dispensing systems have been widely applied as a deposition and patterning tool in various manufacturing processes in the electronics and micro-engineering industries. Examples include patterning electrodes, soldering electric circuits, fabricating multicolor polymer light-emitting diodes or liquid-crystal display color filters, and depositing UV-curable resin [–]. Also, the dispensing system has been adapted to biological and tissue engineering applications, such as producing microarrays with biomolecules and cellular structures including scaffolds [–].
In these applications, volume and velocity of droplets ejected by the dispensing systems substantially influence pattern resolutions during manufacturing processes []. Especially, to ensure highly accurate positioning of droplets in well-defined substrate locations, the velocity and direction of the droplets ejected from the outlet must be uniform []. The velocity of droplets affects how the droplet contacts the substrate (impact process) and how straightly it flies to the substrate (directionality) []. High velocity provides a good directionality of the dispensed droplet but causes droplet splashing during impact process, whereas low velocity induces poor directionality and reduces the precision of positioning []; therefore, if a low-velocity droplet is to reach a desired location on the substrate, the droplet’s flight distance must be short.
For a patterning process to be successful, the velocity of droplets must be controlled, to prevent them from splashing and to achieve accurate and precise directionality. In the most dispensing systems, a droplet’s volume and velocity are both linearly dependent on the magnitude of the driving force or on the transferred kinetic energy [–]. Therefore, in conventional dispensing systems the droplet’s velocity cannot be controlled without affecting its volume.
In this research, we introduce a pneumatic dispensing system to control the velocity of nanoliter droplets with causing small variation in their volume. The system has a flexible membrane which is deflected by applied pressure and concurrently restricted to a designed volume of a dispenser. Because of a dispensing mechanism, the volume and velocity of droplets are regulated by the volume and speed of a membrane deflection which is determined by design parameters and operating conditions. To verify relations between design parameters and the velocity of droplets, we systematically measured volume and velocity of droplets using various designed dispensers. We also measured how the velocity of droplets is affected by the time over which the driving force is applied and the flow resistance at the outlet.
The dispenser has top (glass) and bottom (silicon) substrates separated by a flexible membrane (PDMS film). The bottom substrate includes a liquid chamber, an inlet hole, and a bump structure that functions as a restrictor during the dispensing process (Figure 1(b)). The outlet of the dispenser is oriented sideways and is defined by a dicing process of the assembled substrates. The flexible membrane is deflected by the applied pressure, and thus draws in or dispenses liquid. The membrane is either pulled (negative pressure) or pushed (positive pressure) depending on the programmed electric signal. The applied pressure is normally negative; a pulsed signal switches a solenoid valve to provide positive pressure (during duration time) to dispense the liquid. The liquid is drawn into the chamber when the membrane is pulled (during delay time) and dispensed when it is pushed [].
To characterize the relationship between design parameters and the droplet velocity, dispensers were prepared that had different dimensions: chamber diameter (CD) ranged from 2 mm to 3 mm, and outlet width (OW) from 50 μm to 150 μm. Other design parameters of the dispenser were fixed: 100-μm height of chamber and outlet, 500-μm diameter of inlet hole, and 1000-μm diameter of bump structure. To reduce flow resistance of the outlet, we also prepared a dispenser with short outlet length which is defined by a dicing process.
A. Design parameters of the dispenser
To determine the effect of design parameters (CD and OW), droplet volume and velocity were measured for each design parameter. Positive pressures from 20 kPa to 200 kPa were applied while other operating conditions were fixed: 10-ms duration time, −10-kPa negative pressure, 100-ms delay time, and 1-kPa inlet pressure.
The volume of the droplet dispensed through the outlet was also affected by the flow resistance, which is determined by the outlet size. For outlet width-controlled dispensers at 3-mm CD, the slopes of the plot of droplet volume versus pressure increased with OW (Figure 5(a)) because the flow resistance of the outlet decreases as OW increases. The theoretically calculated flow resistances at 100-μm and 50-μm OW are 2 times and 10 times, respectively, larger than that at 150-μm OW []. Therefore, due to high flow resistance of the outlet, the dispenser with small OW (50 μm) did not reach the saturated volume even at the maximum applied pressure.
Under the same operating condition, velocities of the droplets proportionally increased to about 0.4th power of positive pressure before and after the volume saturation (Figure 5(b)), unlike the trend in droplet volume with pressure. For all design parameters velocities was varied from 1.6 m/s to 8.0 m/s while applied pressures were changed from 20 kPa to 200 kPa. The difference between maximum and minimum velocity at the same positive pressure for each design parameter was ranged from 0.9 m/s to 1.4 m/s. (Unless the result of the 50-μm OW was included, it was ranged from 0.6 m/s to 1.1 m/s.) The velocity of droplets was dominantly affected by applied positive pressure values rather than design parameters such as CD and OW.
The velocity of droplets continuously increased over the applied pressure range even while the volume of droplets was saturated when pressure was about 100 kPa. The dispensing time from emergence of the liquid jet to detachment at the outlet was measured from previously-obtained images (Figure 5(c)). Although the duration time (i.e., solenoid valve opening time) was programmed to be 10 ms, the dispensing time changed according to dispensing condition, which determines the volume and velocity of droplets. The dispensing time tended to decrease after volume saturation to satisfy the continuity condition based on conservation of mass, because the droplet velocity increases with positive pressures. The dispensing time of the dispenser with 50-μm OW constantly increased with the droplet velocity because the droplet volume does not saturated within applied pressures (20 ~ 200 kPa).
B. Duration time of application of positive pressure
In our dispensing mechanism, the amount of input energy transferred to the liquid in the dispenser chamber is determined by the magnitude of positive pressure to the membrane and the duration time over which the pressure is applied. The dispensed volume corresponds to amount of input energy induced by membrane deflection, but the velocity of droplets increased with the magnitude of positive pressure. To determine how input energy affects the dispensed droplet, we measured the volume and velocity with controlled time to apply positive pressure (i.e., driving force).
C. Flow resistance of the outlet
Results of the previous experiment indicate that flow resistance (caused by liquid viscosity) at the outlet of our dispenser affects the volume and velocity of the droplet: small OW decreased droplet volume and velocity due to induced high flow resistance which causes large energy loss. Flow resistance of the outlet depends on its cross-section area and length. To confirm the effect of the flow resistance at the outlet under constant cross-section area, we measured the volume and velocity of droplets using dispensers which had 890-μm (long) and 75-μm (short) outlet length (CD 3 mm and OW 100 μm).
We developed a pneumatic dispensing system to control the velocity of nanoliter droplets with small variation of their volume. The ability of the dispensing system to control droplet velocities was assessed under various design parameters and operating conditions. Droplet volume saturated because the maximum deflected volume of the membrane is limited by the chamber size. Droplet velocity increased depending on applied positive pressure after volume saturation. The velocity of droplets was affected mainly by the magnitude of positive pressure regardless of the duration time over which it was applied. The range of droplet velocities was strongly affected by the flow resistance at the outlet when the cross-section area of the outlet was held constant. The velocity of droplets ejected by our dispensing system can be easily controlled at a desired droplet volume by selecting design parameters and operating conditions that correspond to a specific patterning condition. For successful achievement of a patterning process, this dispensing system will provide a reliable performance within an optimized condition stably to deposit droplets onto accurate locations.
This work was supported by the National Research Foundation of Korea (NRF) grant founded by the Korea government (MSIP) (No. 2011–0030075).
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